Krukenberg carcinoma genetic and rare diseases information. Clinical characteristics and prognostic analysis of krukenberg tumor. Krukenberg tumor is a rare metastatic signet ring cell adenocarcinoma of the ovary. The world health organization who defined it as an ovarian metastasis when the mucussecreting cells of signet ring are present, associated with sarcomatous stromal. This axis of tumor spread has historically drawn the attention of many pathologists, especially when it was found that gastric neoplasms selectively metastasize to the ovaries without involvement of other tissues. The majority are benign, but some can be malignant they are most frequently found incidentally on pelvic examination or at laparotomy. Complication of ovarian tumors torsion common with dermoidfibroma severe abdominal painvomitting rupture. Krukenberg tumor survival rate, prognosis, symptoms. The eponym of this condition was given due by krukenberg initially described in 1896 and the criteria given were 1 the presence of a tumor in the ovary, 2 evidence of intracellular mucin secretion by the formation of signet cells, and 3 diffuse.
It is characterized by areas of mucoid degeneration and the presence of signetringlike cells. Patients of all age groups may develop krukenberg tumor. Carcinomas of colon, appendix, and breast mainly invasive lobular carcinoma are the next most common primary sites. Use the link below to share a fulltext version of this article with your friends and colleagues. Gastric and colorectal cancers together account for almost entire 90% of the pr imary site for the origin of this tumor 5 7. Krukenberg tumor article about krukenberg tumor by the free. We retrospectively analyzed the demographic characteristics, treatment modalities, progression free survival pfs, and overall survival os of patients who were diagnosed with krukenberg tumors of gastric cancer origin and who underwent treatment and followup between january 2005 and january 2012 in the ankara oncology education and research hospital. All structured data from the file and property namespaces is available under the creative commons cc0 license. Krukenberg tumor arising from bilateral lobular carcinoma in. It is still uncertain whether surgical resection of ovarian metastases andor primary tumor could improve the outcome. Complication of ovarian tumors torsion common with dermoidfibroma severe abdominal painvomitting rupture haemorrhage impaction infection 41.
The diagnosis and origins of kt depends on histopathology and immunohistochemistry evaluation ihc. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 toll free. The majority are benign, but some can be malignant. For language access assistance, contact the ncats public information officer. Krukenberg tumor definition of krukenberg tumor by. A case of krukenberg tumor from colon cancer 289 as well as pfs 8.
Krukenberg tumor is a metastatic signet ring cell adenocarcinoma of the ovary, accounting for 1% to 2% of all ovarian tumors. Krukenberg tumor is named after friedrich ernst krukenberg who described five cases of krukenberg tumors in 1896 while working as a student in a laboratory in germany. An uptodate understanding of the krukenberg tumor mechanism. Krukenberg tumor is a rare ovarian metastatic cancer from the gastrointestinal tract. Krukenberg tumor article about krukenberg tumor by the. Krukenberg tumor is more commonly observed among women in the fifth decade, with an average age of presentation at 45 years of age. Carcinomas of colon, appendix, and breast mainly invasive lobular carcinoma are the next most common primary sites 2. In most krukenberg tumor cases, stomach is the main primary site. Krukenberg tumor survival rate, prognosis, symptoms, treatment. H e proposed, instead, a krukenberga s metastatic ovarian carcinoma. May 12, 2006 krukenberg tumor is an example of the selective spread of cancers, most commonly in the stomachovarian axis. Krukenbergs tumor article about krukenbergs tumor by the. Prenatal or intrapartum predictive factors are only identified in 30% of cases, although none, except placenta previa, accreta and abruptio, have sufficient odds ratiospecificitysensitivity to warrant prevention strategies. Brenner tumors are an uncommon subtype of the surface epithelialstromal tumor group of ovarian neoplasms.
A krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site, classically the gastrointestinal tract, although it can arise in other tissues such as the breast. A 36yearold female with krukenberg tumor from a colonic. The prognosis of a patient with krukenberg tumor is extremely poor with average survival time between 3 and 10 months. Kim sh, kim wh, park kj, lee jk, kim js 1996 ct and mr findings of krukenberg tumors. Treatments and overall survival in patients with krukenberg tumor. An adnexal mass in pregnancy is a malignant tumor in 25% of cases. Krukenberg tumor is a metastatic cancerous development spread from stomach to ovary. By krukenberg termed fibrosarcoma ovarii mucocellulare carcinomatodes, but they are now known to be most frequently secondary to malignancy of the gastrointestinal tract. Krukenberg tumor is an uncommon ovarian carcinoma containing mucin filled signet ring cells and constituting 12% of all ovarian tumors. Gastric adenocarcinoma, especially at the pylorus, is the most common source. The development of the krukenberg tumor is not from general gastric cancer, but it is a specific form of cancerous growth arises from signet ring cell carcinoma of the stomach and spread to adenocarcinoma of the ovary.
The stomach is the primary site in the majority of krukenberg tumor cases, followed by carcinomas of the colon, appendix and breast, particularly invasive lobular carcinoma. Krukenbergs tumor article about krukenbergs tumor by. Krukenberg tumor most commonly metastasizes from gastric carcinoma, particularly adenocarcinoma of stomach. Diagnostic problem schiller emphasized that this, also, was a poor choice, because the name was used loosely to include all varieties 01 metastatic carcinoma to the ovary. Apr 17, 2014 krukenberg tumor most commonly metastasizes from gastric carcinoma, particularly adenocarcinoma of stomach. It derives its name from a german gynecologist and pathologist, friedrick krukenberg who described this tumor as a new type of ovarian neoplasm. Krukenberg tumor kt is a rare secondary ovarian tumor. Treatment of patients with krukenberg tumor is controversial. The eponym was attributed to this tumor following the description of 5 cases by. Krukenberg tumor definition of krukenberg tumor by medical.
Krukenberg tumor medical definition merriamwebster. The route of metastatsis of this rare condition is still not proven. The development of the krukenberg tumor is not from general gastric cancer, but it is a specific form of cancerous growth arises from signet ring cell carcinoma of the stomach and spread to adenocarcinoma of the ovary the primary place of development of the krukenberg tumor is the stomach, but other primary. Elles sont rares et representent 1 a 2 % des tumeurs ovariennes. A tumor of the ovary that is caused by the spread of metastatic cancer of the gastrointestinal tract, characteristically from the stomach. Files are available under licenses specified on their description page. Krukenbergs tumor definition of krukenbergs tumor by. Ovarian cancer occurs in one in 8000 to one in 25,000 pregnancies. The covariates used for survival analysis were patient age at the time of ovarian relapse categorized as 50 years, size of krukenbergs tumor categorized as 10 cm, initial ajcc stage of gastric carcinoma, relapse free interval categorized as 2 years, extent of recurrent disease, and the. The tumors represent 510% of all ovarian tumors and up to 50% of all. The other sites implicated for krukenberg tumor are breast invasive lobular breast carcinoma, appendix, colon, small intestine, rectum, urinary bladder, gallbladder, biliary tract, pancreas, ampulla of vater and uterine cervix. Literature says that primary debulking can be done for a metastatic disease like krukenberg. Typically, the tumor is a large, greyish white, solid lesion. Electronic databases were searched from their inception to february 2019 for studies assessing the association of clinicopathologic factors with.
Prognostic factors in krukenberg tumor springerlink. A tumor of the ovary that is caused by the spread of metastatic cancer of the gastrointestinal tract. Krukenberg tumor was first described as a new type of primary ovarian malignancy by friedrich ernst krukenberg 18711946, a german. A case of krukenberg tumor metastasized from colon.
Kt is typically characterized by mucin secreting signet ring cell adenocarcinoma lying in the fibroblastic. Krukenberg tumor is typically free of surface adhesions or peritoneal deposits unlike other ovarian metastasis. Bilateral ovarian krukenberg tumor in a fullterm pregnancy. Stomach is the primary site in most krukenberg tumors 70%. Obstetric haemorrhage is a leading cause of maternal and foetal morbidity and mortality. The colon and stomach are the most common primary tumors to result in ovarian metastases, followed by the breast, lung, and contralateral ovary. Brenner tumours very rarely can occur in other locations, including the testes. Krukenberg tumor has characteristic tanwhite bosselated appearance with preservation of the contour and free of adhesions. Krukenberg tumor kt is a rare metastatic ovarian tumor mostly originating from gastrointestinal gi malignancy, and accounts for 12% of all ovarian tumors.
A case report of krukenberg tumors secondary to adenocarcinoma of gall bladder also, ovarian metastases, including krukenberg tumors, may be mistaken as a solid sexcord stromal tumor and can appear as solid or complex ovarian. From mucin secreting tumors, stomach and colon krukenberg tumors may be secondary to breast 39. A case of krukenberg tumor metastasized from colon cancer. It accounts for 1%5% of malignant tumors of the ovaries, usually being bilateral, of solid consistency and may have cystic areas. Krukenberg tumours are not a common disease entity, forming 12% of all ovarian tumours. Little is known about clinicopathologic factors affecting prognosis in kt. They are most frequently found incidentally on pelvic examination or at laparotomy. A krukenberg tumor refers to a malignancy in the ovary that is metastasized from a primary site, classically the gastrointestinal tract. Krukenberg tumor is usually but not always a bilateral involvement of ovaries from metastatic deposit from adenocarcinoma of stomach and rarely from other gastrointestinal gi and non gi organs. After extensive investigations she was diagnosed to have primary gastric malignancy with carcinoma of recto sigmoid and krukenberg tumor.
Sep 21, 2019 krukenberg tumor kt is a rare secondary ovarian tumor. Some studies have shown stomach cancer to be primary site in about 70% of krukenberg tumor cases 5. Krukenberg tumor is a rare metastatic signet ring cell tumor of the ovary, accounting for 12% of all ovarian tumors. Krukenberg tumor, also known as carcinoma mucocellulare, refers to the signet ring subtype of metastatic tumor to the ovary. Clinical characteristics and prognostic analysis of. If you have problems viewing pdf files, download the latest version of adobe reader. Krukenberg tumor is an example of the selective spread of cancers, most commonly in the stomachovarian axis. A malignant tumor of the ovary, usually bilateral, with fibromyxomatous stroma and scattered mucin secreting signet cells. May 10, 2012 from mucin secreting tumors, stomach and colon krukenberg tumors may be secondary to breast 39.
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